If you find yourself:

• having huge .xaml.cs code behind file
• using event handler (such as Click…) everywhere
• tweaking TreeViewItem (using ItemContainerGenerator for example) to manipulate a TreeView
• having tons of IValueConverter
• … then MVVM might come to the rescue :p

What MVVM can offer?

• a clean and well defined separation between the Model and the View
• the possibility to easily leverage the power of WPF: databinding, commands, validation, and more
• a code that is testable
• an organization that facilitate the workflow between designers and developers
• minimalist code-behind file (which leads to testable code)
• facilitate the deployment of an application in multiple environment (WPF / Silverlight)

How is that possible?

Here is a part of the introduction of John Gossman:

“In simple examples, the View is data bound directly to the Model. For example, a boolean in the Model can be data bound to a CheckBox, or a string field to a TextBox. In practice however, only a small subset of application UI can be data bound directly to the Model, especially if the Model is a pre-existing class or data schema over which the application developer has no control.
The Model is very likely to have a data types that cannot be mapped directly to controls.  Finally we need a place to put view state such as selection or modes.
The ViewModel is responsible for these tasks.  In this latter role the ViewModel contains data-transformers that convert Model types into View types, and it contains Commands the View can use to interact with the Model.”

• The View has the associated ViewModel set as its DataContext so that the View can easily data bind to ViewModel properties
• The ViewModel reflects its changes to the Model by calling appropriate methods on the Model
• The ViewModel exposes ICommand that the View data bind to, in order to execute actions
• The Model signals its changes to the ViewModel by raising events

What are good resources to start working with MVVM?

• Karl Shifflett started a series about MVVM, you can find his work here.
• Karl and Josh Smith wrote a very nice application that uses MVVM pattern. Moreover the application contains also information about internalization support. Check out the CodeProject article here.
• Karl wrote an article about a very important concept: user input validation. This is the first article of his new MVVM series.
• WPF architect, John Gossman wrote a series of blog post about MVVM on his blog. An introduction to MVVM is available and a good point to start.
• Josh Smith wrote an excellent tool, Crack.Net which is built using MVVM. Crack.Net is hosted on CodePlex, and studying the source code is a very good manner to understand how stuff fits together in the MVVM world.
• Josh Smith wrote an article about applying MVVM concepts to the WPF treeview. If you must work with a complex treeview, then you MUST read this article.
• Marlon Grech wrote an article about ICollectionView. ICollectionView is a useful interface that can be used in ViewModel classes to keep track user selection

If you never heard about MVVM, or never take the time to look at it, I suggest you to take a look at some of those links. Trust me, the investisment worth it !